Robust strategies in nuclear-targeted cancer therapy based on functional nanomaterials

Schematic illustration of several nuclear-targeted drug delivery strategies, such as charge conversion, size ladder, dual targeting, light irradiation and stimulated responsive, for enhanced gene therapy, chemotherapy, phototherapy, combination therapy CRISPE genome editing based therapy. • Recent advances functional nanomaterials in cancer are overviewed. Many nuclear targeting ligands introduced to understand entry mechanism. The robust strategies summarized improve the nanocarriers. Current challenges clinical applications future perspectives discussed. Nucleus, machinery transcription, play prominent roles support fundamental cellular functions, destruction any these specific parts would significantly modulate cell function. Therefore, troumendous systems with nucleus ability have been studied nucleus-related disease regulation. purpose this review is sort out strategy, especially active mechanism various their extensive on Various first Next, overcome biological barriers avoid serum protein absorption, diverse different Moreover, other sophisticated carrier entry, while without also assembled. At end opportunities field nanotherapeutics tentatively proposed, speed up translation.